BMCBI
2006
13 years 5 months ago
2006
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
BMCBI
2006
13 years 5 months ago
2006
Background: Detection of periodically expressed genes from microarray data without use of known periodic and non-periodic training examples is an important problem, e.g. for ident...
BMCBI
2006
13 years 5 months ago
2006
Background: After complete sequencing of a number of genomes the focus has now turned to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass spectrometry e...
BMCBI
2006
13 years 5 months ago
2006
Background: In a microarray experiment the difference in expression between genes on the same slide is up to 103 fold or more. At low expression, even a small error in the estimat...
BMCBI
2006
13 years 5 months ago
2006
Background: We present a general approach to perform association analyses in pedigrees of arbitrary size and structure, which also allows for a mixture of pedigree members and ind...
BMCBI
2006
13 years 5 months ago
2006
Background: The choice of probe set algorithms for expression summary in a GeneChip study has a great impact on subsequent gene expression data analysis. Spiked-in cRNAs with know...
BMCBI
2006
13 years 5 months ago
2006
Background: Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple ...
BMCBI
2006
13 years 5 months ago
2006
Background: Simulation of DNA-microarray data serves at least three purposes: (i) optimizing the design of an intended DNA microarray experiment, (ii) comparing existing pre-proce...
BMCBI
2006
13 years 5 months ago
2006
Background: Character mapping on phylogenies has played an important, if not critical role, in our understanding of molecular, morphological, and behavioral evolution. Until very ...
BMCBI
2006
13 years 5 months ago
2006
Background: The increasing availability of time-series expression data opens up new possibilities to study functional linkages of genes. Present methods used to infer functional l...