BMCBI
2007
13 years 5 months ago
2007
Background: With the increased availability of high throughput data, such as DNA microarray data, researchers are capable of producing large amounts of biological data. During the...
BMCBI
2007
13 years 5 months ago
2007
Background: It is becoming increasingly important for researchers to be able to scan through large genomic regions for transcription factor binding sites or clusters of binding si...
BMCBI
2007
13 years 5 months ago
2007
Background: The recent increase in the use of high-throughput two-hybrid analysis has generated large quantities of data on protein interactions. Specifically, the availability of...
BMCBI
2007
13 years 5 months ago
2007
Background: Maximum parsimony phylogenetic tree reconstruction from genetic variation data is a fundamental problem in computational genetics with many practical applications in p...
BMCBI
2007
13 years 5 months ago
2007
Background: Whereas the molecular assembly of protein expression clones is readily automated and routinely accomplished in high throughput, sequence verification of these clones i...
BMCBI
2007
13 years 5 months ago
2007
Background: During generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to prop...
BMCBI
2007
13 years 5 months ago
2007
Background: Genome-wide identification of specific oligonucleotides (oligos) is a computationallyintensive task and is a requirement for designing microarray probes, primers, and ...
BMCBI
2007
13 years 5 months ago
2007
BMCBI
2007
2007
Missing channels in two-colour microarray experiments: Combining single-channel and two-channel data
13 years 5 months ago
Background: There are mechanisms, notably ozone degradation, that can damage a single channel of two-channel microarray experiments. Resulting analyses therefore often choose betw...
BMCBI
2007
13 years 5 months ago
2007
Background: Over the past decade, a number of tools have emerged for the examination of homology relationships among protein sequences in a structural context. Most recent softwar...