BIOINFORMATICS
2011
12 years 12 months ago
2011
Motivation: Analysis and intervention in the dynamics of gene regulatory networks is at the heart of emerging efforts in the development of modern treatment of numerous ailments i...
NAR
2007
13 years 4 months ago
2007
Transcriptional factors (TFs) and many of their target genes are involved in gene regulation at the level of transcription. To decipher gene regulatory networks (GRNs) we require ...
PRL
2006
13 years 4 months ago
2006
This paper proposes a novel method for gene selection. In the method, the gene regulation, an important mechanism of gene activities, is first introduced, and then the probabiliti...
JCB
2008
13 years 4 months ago
2008
Resolving the general organizational principles that govern the interactions during transcriptional gene regulation has great relevance for understanding disease progression, biof...
BMCBI
2006
13 years 4 months ago
2006
Background: Microarray expression profiling has been widely used to identify differentially expressed genes in complex cellular systems. However, while such methods can be used to...
BMCBI
2006
13 years 4 months ago
2006
Background: Discovery of precise specificity of transcription factors is an important step on the way to understanding the complex mechanisms of gene regulation in eukaryotes. Rec...
BMCBI
2006
13 years 4 months ago
2006
Background: Gene regulation and metabolic reactions are two primary activities of life. Although many works have been dedicated to study each system, the coupling between them is ...
BMCBI
2008
13 years 4 months ago
2008
Background: The rate of mRNA transcription is controlled by transcription factors that bind to specific DNA motifs in promoter regions upstream of protein coding genes. Recent res...
APBC
2004
13 years 6 months ago
2004
The conserved sequences in gene regulatory regions dominate gene regulation. Discovering these sequences and their functions is important in post genome era. A novel model is cons...
MIE
2008
13 years 6 months ago
2008
The Gene Regulation Ontology (GRO) is designed as a novel approach to model complex events that are part of the gene regulatory processes. We introduce the design requirements for ...