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RECOMB
2006
Springer
10 years 11 months ago
Detecting MicroRNA Targets by Linking Sequence, MicroRNA and Gene Expression Data
MicroRNAs (miRNAs) have recently been discovered as an important class of non-coding RNA genes that play a major role in regulating gene expression, providing a means to control th...
Jim C. Huang, Quaid Morris, Brendan J. Frey
RECOMB
2006
Springer
10 years 11 months ago
Structural Alignment of Pseudoknotted RNA
In this paper, we address the problem of discovering novel non-coding RNA (ncRNA) using primary sequence, and secondary structure conservation, focusing on ncRNA families with pseu...
Banu Dost, Buhm Han, Shaojie Zhang, Vineet Bafna
RECOMB
2006
Springer
10 years 11 months ago
CONTRAlign: Discriminative Training for Protein Sequence Alignment
In this paper, we present CONTRAlign, an extensible and fully automatic framework for parameter learning and protein pairwise sequence alignment using pair conditional random field...
Chuong B. Do, Samuel S. Gross, Serafim Batzoglou
RECOMB
2006
Springer
10 years 11 months ago
Leveraging Information Across HLA Alleles/Supertypes Improves Epitope Prediction
We present a model for predicting HLA class I restricted CTL epitopes. In contrast to almost all other work in this area, we train a single model on epitopes from all HLA alleles a...
David Heckerman, Carl Myers Kadie, Jennifer Listga...
RECOMB
2006
Springer
10 years 11 months ago
Maximal Accurate Forests from Distance Matrices
Abstract. We present a fast converging method for distance-based phylogenetic inference, which is novel in two respects. First, it is the only method (to our knowledge) to guarante...
Constantinos Daskalakis, Cameron Hill, Alexander J...
RECOMB
2006
Springer
10 years 11 months ago
Detecting the Dependent Evolution of Biosequences
Abstract. A probabilistic graphical model is developed in order to detect the dependent evolution between different sites in biological sequences. Given a multiple sequence alignme...
Jeremy Darot, Chen-Hsiang Yeang, David Haussler
RECOMB
2006
Springer
10 years 11 months ago
A Probabilistic Model for Gene Content Evolution with Duplication, Loss, and Horizontal Transfer
We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gen...
István Miklós, Miklós Csü...
RECOMB
2006
Springer
10 years 11 months ago
Assessing Significance of Connectivity and Conservation in Protein Interaction Networks
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
RECOMB
2006
Springer
10 years 11 months ago
Predicting Experimental Quantities in Protein Folding Kinetics Using Stochastic Roadmap Simulation
Abstract. This paper presents a new method for studying protein folding kinetics. It uses the recently introduced Stochastic Roadmap Simulation (SRS) method to estimate the transit...
Tsung-Han Chiang, Mehmet Serkan Apaydin, Douglas L...
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