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BIB
2010
103views more  BIB 2010»
9 years 6 months ago
Challenges of sequencing human genomes
Massively parallel sequencing technologies continue to alter the study of human genetics. As the cost of sequencing declines, next-generation sequencing (NGS) instruments and data...
Daniel C. Koboldt, Li Ding, Elaine R. Mardis, Rich...
WABI
2010
Springer
172views Bioinformatics» more  WABI 2010»
9 years 7 months ago
Fast Mapping and Precise Alignment of AB SOLiD Color Reads to Reference DNA
Abstract. Applied Biosystems’ SOLiD system offers a low-cost alternative to the traditional Sanger method of DNA sequencing. We introduce two main algorithms of mapping SOLiD’...
Miklós Csürös, Szilveszter Juhos,...
SCFBM
2008
91views more  SCFBM 2008»
9 years 8 months ago
Simple tools for assembling and searching high-density picolitre pyrophosphate sequence data
Background: The advent of pyrophosphate sequencing makes large volumes of sequencing data available at a lower cost than previously possible. However, the short read lengths are d...
Nicolas J. Parker, Andrew G. Parker
EOR
2008
80views more  EOR 2008»
9 years 8 months ago
An efficient implementation of a VNS/ILS heuristic for a real-life car sequencing problem
The car sequencing problem consists in sequencing a given set of cars to be produced in a single day. We address one of the variants of this problem, in which the objective of mini...
Celso C. Ribeiro, Daniel Aloise, Thiago F. Noronha...
BMCBI
2010
81views more  BMCBI 2010»
9 years 9 months ago
Empirical Bayes Analysis of Sequencing-based Transcriptional Profiling without Replicates
Background: Recent technological advancements have made high throughput sequencing an increasingly popular approach for transcriptome analysis. Advantages of sequencing-based tran...
Zhijin Wu, Bethany D. Jenkins, Tatiana A. Rynearso...
BMCBI
2004
86views more  BMCBI 2004»
9 years 9 months ago
A computer simulation analysis of the accuracy of partial genome sequencing and restriction fragment analysis in estimating gene
Background: Determination of genetic relatedness among microorganisms provides information necessary for making inferences regarding phylogeny. However, there is little informatio...
Baozhen Qiao, Ronald M. Weigel
AC
2004
Springer
9 years 9 months ago
Shotgun Sequence Assembly
Shotgun sequencing is the most widely used technique for determining the DNA sequence of organisms. It involves breaking up the DNA into many small pieces that can be read by auto...
Mihai Pop
TSMC
2008
94views more  TSMC 2008»
9 years 9 months ago
Test Sequencing in Complex Manufacturing Systems
Testing complex manufacturing systems, such as an ASML [1] lithographic machine, takes up to 45% of the total development time of a system. The problem of which tests must be execu...
R. Boumen, I. S. M. de Jong, J. W. H. Vermunt, J. ...
BMCBI
2005
114views more  BMCBI 2005»
9 years 9 months ago
Extension of Lander-Waterman theory for sequencing filtered DNA libraries
Background: The degree to which conventional DNA sequencing techniques will be successful for highly repetitive genomes is unclear. Investigators are therefore considering various...
Michael C. Wendl, W. Bradley Barbazuk
BMCBI
2005
90views more  BMCBI 2005»
9 years 9 months ago
An algorithm for the determination and quantification of components of nucleic acid mixtures based on single sequencing reaction
Background: Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches, where the mixtures are hybridized against sp...
Alexander E. Pozhitkov, Kathryn Stemshorn, Diethar...
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