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BMCBI
2006

An Automated Method for Rapid Identification of Putative Gene Family Members in Plants

13 years 2 months ago
An Automated Method for Rapid Identification of Putative Gene Family Members in Plants
Background: Gene duplication events have played a significant role in genome evolution, particularly in plants. Exhaustive searches for all members of a known gene family as well as the identification of new gene families has become increasingly important. Subfunctionalization via changes in regulatory sequences following duplication (adaptive selection) appears to be a common mechanism of evolution in plants and can be accompanied by purifying selection on the coding region. Such negative selection can be detected by a bias toward synonymous over nonsynonymous substitutions. However, the process of identifying this bias requires many steps usually employing several different software programs. We have simplified the process and significantly shortened the time required by condensing many steps into a few scripts or programs to rapidly identify putative gene family members beginning with a single query sequence. Results: In this report we 1) describe the software tools (SimESTs, PCAT,...
Ronald L. Frank, Ajay Mane, Fikret Erçal
Added 10 Dec 2010
Updated 10 Dec 2010
Type Journal
Year 2006
Where BMCBI
Authors Ronald L. Frank, Ajay Mane, Fikret Erçal
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