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BMCBI
2004

A database for G proteins and their interaction with GPCRs

13 years 10 months ago
A database for G proteins and their interaction with GPCRs
Background: G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming heterotrimers composed of different subunits (,,). The subunit of the G protein is responsible for the recognition of a given GPCR. Whereas specialised resources for GPCRs, and other groups of receptors, are already available, currently, there is no publicly available database focusing on G Proteins and containing information about their coupling specificity with their respective receptors. Description: gpDB is a publicly accessible G proteins/GPCRs relational database. Including species homologs, the database contains detailed information for 418 G protein monomers (272 G, 87 G and 59 G) and 2782 GPCRs sequences belonging to families with known coupling to G proteins. The GPCRs and the G proteins are classified according to a hierarchy of different classes, families and sub-families, based on extensive lite...
Antigoni L. Elefsinioti, Pantelis G. Bagos, Ioanni
Added 16 Dec 2010
Updated 16 Dec 2010
Type Journal
Year 2004
Where BMCBI
Authors Antigoni L. Elefsinioti, Pantelis G. Bagos, Ioannis C. Spyropoulos, Stavros J. Hamodrakas
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