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BMCBI
2007

Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control

14 years 5 days ago
Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control
Background: The progress in the "-omic" sciences has allowed a deeper knowledge on many biological systems with industrial interest. This knowledge is still rarely used for advanced bioprocess monitoring and control at the bioreactor level. In this work, a bioprocess control method is presented, which is designed on the basis of the metabolic network of the organism under consideration. The bioprocess dynamics are formulated using hybrid rigorous/data driven systems and its inherent structure is defined by the metabolism elementary modes. Results: The metabolic network of the system under study is decomposed into elementary modes (EMs), which are the simplest paths able to operate coherently in steady-state. A reduced reaction mechanism in the form of simplified reactions connecting substrates with end-products is obtained. A dynamical hybrid system integrating material balance equations, EMs reactions stoichiometry and kinetics was formulated. EMs kinetics were defined as t...
Ana P. Teixeira, Carlos Alves, Paula M. Alves, Man
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Ana P. Teixeira, Carlos Alves, Paula M. Alves, Manuel J. T. Carrondo, Rui Oliveira
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