Imaging Tumor Microenvironment with Ultrasound

13 years 3 months ago
Imaging Tumor Microenvironment with Ultrasound
Abstract. Recent advances in molecular biology are providing new opportunities for breast cancer imaging. Our approach uses ultrasound to image viscoelastic features of tumors. These features describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics. This paper explains the motivation for the approach, describes measurements in phantoms and patients, and defines measurement sensitivity using hydrogels with tissue-like features. 1 Viscoelastic Imaging of the Tumor Microenvironment Cancer cells communicate locally with other cells and the extracellular matrix (ECM) using molecular signals. Communication is essential if a cancerous tumor is to grow and metastasize [Ele01]. Molecular signaling controls many facets of tumor progression related to outcome including growth rate, degree of invasiveness, and metastatic potential. Signals are generated in response to the tissue microenvir...
Mallika Sridhar, Michael F. Insana
Added 27 Jun 2010
Updated 27 Jun 2010
Type Conference
Year 2005
Where IPMI
Authors Mallika Sridhar, Michael F. Insana
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