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BMCBI
2008

InteroPORC: an automated tool to predict highly conserved protein interaction networks

13 years 10 months ago
InteroPORC: an automated tool to predict highly conserved protein interaction networks
teps. First, we abstracted protein interactions onto orthologous cluster links. For a given source interaction, if both proteins belonged to a cluster, we constructed a link between these two clusters. In the second step, we projected these cluster links onto a specific target species. Practically, for a given link, if both clusters contained a protein from the target species, we predicted an interaction between these proteins. Results We applied our automated prediction tool to the cyanobacteria Synechocystis. It enabled us to predict a new network of 1,463 protein-protein interactions when less than 200 interactions were experimentally annotated in the databases. In the same way, we predicted for instance 13,469 interactions for the rat. Availability This open-source application can either be run online through a web interface or downloaded at http:// biodev.extra.cea.fr/interoporc/. To run the tool online, we have collected source interactions from the three manually curated databas...
Magali Michaut, Samuel Kerrien, Luisa Montecchi-Pa
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Magali Michaut, Samuel Kerrien, Luisa Montecchi-Palazzi, Corinne Cassier-Chauvat, Franck Chauvat, Jean-Christophe Aude, Pierre Legrain, Henning Hermjakob
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