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JCNS
2000

Models of Calmodulin Trapping and CaM Kinase II Activation in a Dendritic Spine

13 years 5 months ago
Models of Calmodulin Trapping and CaM Kinase II Activation in a Dendritic Spine
Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Here a model of calmodulin binding and trapping by CaMKII in a dendritic spine was used to estimate levels and durations of CaMKII activation following LTP-inducing tetani. The calcium signal was calcium influx through NMDA receptor channels computed in a highly detailed dentate granule cell model. Calcium could bind to calmodulin and calmodulin to CaMKII. CaMKII subunits were either free, bound with calmodulin, trapped, autonomous, or capped. Strong low-frequency tetanic input produced little calmodulin trapping or CaMKII activation. Strong high-frequency tetanic input caused large numbers of CaMKII subunits to become trapped, and CaMKII was strongly activated. Calmodulin trapping and CaMKII activation were highly dependent on tetanus frequency (particularly between 10 and 100 Hz) and were highly sensitive to relativel...
William Holmes
Added 18 Dec 2010
Updated 18 Dec 2010
Type Journal
Year 2000
Where JCNS
Authors William Holmes
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