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CIBCB
2008
IEEE

Network motifs in context: An exploration of the evolution of oscillatory dynamics in transcriptional networks

14 years 2 months ago
Network motifs in context: An exploration of the evolution of oscillatory dynamics in transcriptional networks
The concept of a network motif--a small set of interacting genes which produce a predictable behaviour at the network level--has attracted considerable attention amongst network analysts. It is of particular interest to synthetic biology, a new discipline which aims to apply engineering principles to biological systems. The modular nature of network motifs would make them ideal candidates for the basic components of an engineered organism. In this paper we investigate the relationship between the presence of network motifs and oscillatory dynamics in a yeast transcriptional network and a set of computational networks, evolved to exhibit oscillatory behaviour. Our results do not support the hypothesis that network motifs are critical to network dynamics, possibly because they are tightly connected to many other components of the complex cell-wide transcriptional network.
Jennifer Hallinan, Anil Wipat
Added 12 Oct 2010
Updated 12 Oct 2010
Type Conference
Year 2008
Where CIBCB
Authors Jennifer Hallinan, Anil Wipat
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