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DNA
2003
Springer

One Dimensional Boundaries for DNA Tile Self-Assembly

13 years 7 months ago
One Dimensional Boundaries for DNA Tile Self-Assembly
In this paper we report the design and synthesis of DNA molecules (referred to as DNA tiles) with specific binding interactions that guide self-assembly to make one-dimensional assemblies shaped as lines, V’s and X’s. These DNA tile assemblies have been visualized by atomic force microscopy. The highly-variable distribution of shapes – e.g., the length of the arms of X-shaped assemblies – gives us insight into how the assembly process is occurring. Using stochastic models that simulate addition and dissociation of each type of DNA tile, as well as simplified models that more cleanly examine the generic phenomena, we dissect the contribution of accretion vs aggregation, reversible vs irreversible and seeded vs unseeded assumptions for describing the growth processes. The results suggest strategies for controlling self-assembly to make more uniformly-shaped assemblies.
Rebecca Schulman, Shaun Lee, Nick Papadakis, Erik
Added 06 Jul 2010
Updated 06 Jul 2010
Type Conference
Year 2003
Where DNA
Authors Rebecca Schulman, Shaun Lee, Nick Papadakis, Erik Winfree
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