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BMCBI
2010

Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks

13 years 10 months ago
Uncovering packaging features of co-regulated modules based on human protein interaction and transcriptional regulatory networks
Background: Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological functions in their network neighbouring regions. Results: Here, we weighted edges of a human protein interaction network and a transcriptional regulatory network to construct an integrated network, and introduce a probabilistic model and a bipartite graph framework to exploit human co-regulated modules and uncover their specific features in packaging different biological entities (genes, protein complexes or metabolic pathways). Finally, we identified 96 human co-regulated modules based on this method, and evaluate its effectiveness by comparing it with four other methods. Conclusions: Dysfunctions in co-regulated interactions often occur in the development of cancer. Therefore, we focussed on an example co-regulated module and found that it could integrate a number of cancer-related genes. This was extended to...
Lina Chen, Hong Wang, Liangcai Zhang, Wan Li, Qian
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2010
Where BMCBI
Authors Lina Chen, Hong Wang, Liangcai Zhang, Wan Li, Qian Wang, Yukui Shang, Yuehan He, Weiming He, Xu Li, Jingxie Tai, Xia Li
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