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BMCBI
2010
125views more  BMCBI 2010»
14 years 10 months ago
Haplotype allelic classes for detecting ongoing positive selection
Background: Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures in underlying genomic segments that can be r...
Julie Hussin, Philippe Nadeau, Jean-Françoi...
BMCBI
2010
161views more  BMCBI 2010»
14 years 10 months ago
CGHpower: exploring sample size calculations for chromosomal copy number experiments
Background: Determining a suitable sample size is an important step in the planning of microarray experiments. Increasing the number of arrays gives more statistical power, but ad...
Ilari Scheinin, Jose A. Ferreira, Sakari Knuutila,...
BMCBI
2010
120views more  BMCBI 2010»
14 years 10 months ago
Modeling expression quantitative trait loci in data combining ethnic populations
Background: Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression quantitative trait loci (eQTL) compared to...
Ching-Lin Hsiao, Ie-Bin Lian, Ai-Ru Hsieh, Cathy S...
BMCBI
2010
136views more  BMCBI 2010»
14 years 10 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
BIOSYSTEMS
2007
107views more  BIOSYSTEMS 2007»
14 years 10 months ago
Calcium signalling in astrocytes and modulation of neural activity
Up to few years ago astrocytes have been considered as passive elements of brain, providing structural and metabolic support to the neurons, but playing little role in information...
Angelo Di Garbo, Michele Barbi, Santi Chillemi, Su...
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