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» A Computational Approach to Binding Theory
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BIB
2005
149views more  BIB 2005»
14 years 11 months ago
Biomolecular Interaction Network Database
The Biomolecular Interaction Network Database (BIND) (http://bind.ca) archives biomolecular interaction, reaction, complex and pathway information. Our aim is to curate the detail...
Don Gilbert
RECOMB
2005
Springer
16 years 21 hour ago
Predicting Protein-Peptide Binding Affinity by Learning Peptide-Peptide Distance Functions
Many important cellular response mechanisms are activated when a peptide binds to an appropriate receptor. In the immune system, the recognition of pathogen peptides begins when th...
Chen Yanover, Tomer Hertz
GCB
2005
Springer
96views Biometrics» more  GCB 2005»
15 years 5 months ago
Thermodynamics of RNA-RNA Binding
We present an extension of the standard partition function approach to RNA secondary structures that computes the probabilities Pu[i, j] that a sequence interval [i, j] is unpaired...
Ulrike Mückstein, Hakim Tafer, Jörg Hack...
BMCBI
2008
133views more  BMCBI 2008»
14 years 11 months ago
CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated
Background: The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false po...
Matthew S. Hestand, Michiel van Galen, Michel P. V...
BMCBI
2010
105views more  BMCBI 2010»
14 years 12 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang