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RECOMB
2010
Springer
13 years 8 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
GECCO
1999
Springer
130views Optimization» more  GECCO 1999»
13 years 10 months ago
Heterochrony and Adaptation in Developing Neural Networks
This paper discusses the simulation results of a model of biological development for neural networks based on a regulatory genome. The model’s results are analyzed using the fra...
Angelo Cangelosi
BMCBI
2005
98views more  BMCBI 2005»
13 years 6 months ago
Iterative approach to model identification of biological networks
Background: Recent advances in molecular biology techniques provide an opportunity for developing detailed mathematical models of biological processes. An iterative scheme is intr...
Kapil G. Gadkar, Rudiyanto Gunawan, Francis J. Doy...
BMCBI
2010
111views more  BMCBI 2010»
13 years 6 months ago
Functional Analysis: Evaluation of Response Intensities - Tailoring ANOVA for Lists of Expression Subsets
Background: Microarray data is frequently used to characterize the expression profile of a whole genome and to compare the characteristics of that genome under several conditions....
Fabrice Berger, Bertrand De Meulder, Anthoula Gaig...
BMCBI
2007
139views more  BMCBI 2007»
13 years 6 months ago
Bioinformatics analysis of the early inflammatory response in a rat thermal injury model
Background: Thermal injury is among the most severe forms of trauma and its effects are both local and systemic. Response to thermal injury includes cellular protection mechanisms...
Eric Yang, Timothy Maguire, Martin L. Yarmush, Fra...