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CPM
1999
Springer
99views Combinatorics» more  CPM 1999»
15 years 2 months ago
On the Complexity of Positional Sequencing by Hybridization
In sequencing by hybridization (SBH), one has to reconstruct a sequence from its l-long substrings. SBH was proposed as an alternative to gel-based DNA sequencing approaches, but ...
Amir Ben-Dor, Itsik Pe'er, Ron Shamir, Roded Shara...
AB
2007
Springer
15 years 1 months ago
Efficient Haplotype Inference with Pseudo-boolean Optimization
Abstract. Haplotype inference from genotype data is a key computational problem in bioinformatics, since retrieving directly haplotype information from DNA samples is not feasible ...
Ana Graça, João Marques-Silva, In&ec...
DNA
2006
Springer
126views Bioinformatics» more  DNA 2006»
15 years 1 months ago
On the Complexity of Graph Self-assembly in Accretive Systems
We study the complexity of the Accretive Graph Assembly Problem (AGAP). An instance of AGAP consists of an edge-weighted graph G, a seed vertex in G, and a temperature . The goal i...
Stanislav Angelov, Sanjeev Khanna, Mirkó Vi...
CANDC
2006
ACM
14 years 9 months ago
Dealing with repetitions in sequencing by hybridization
DNA sequencing by hybridization (SBH) induces errors in the biochemical experiment. Some of them are random and disappear when the experiment is repeated. Others are systematic, i...
Jacek Blazewicz, Fred Glover, Marta Kasprzak, Wojc...
MST
2006
149views more  MST 2006»
14 years 9 months ago
Parameterized Intractability of Distinguishing Substring Selection
A central question in computational biology is the design of genetic markers to distinguish between two given sets of (DNA) sequences. This question is formalized as the NP-comple...
Jens Gramm, Jiong Guo, Rolf Niedermeier