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» A Design Method for Object-Oriented Programming
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BMCBI
2011
14 years 9 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman
SC
2009
ACM
15 years 9 months ago
Enabling high-fidelity neutron transport simulations on petascale architectures
The UNIC code is being developed as part of the DOE’s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program. UNIC is an unstructured, deterministic neutron transport c...
Dinesh K. Kaushik, Micheal Smith, Allan Wollaber, ...
DAC
2009
ACM
15 years 9 months ago
Clock skew optimization via wiresizing for timing sign-off covering all process corners
Manufacturing process variability impacts the performance of synchronous logic circuits by means of its effect on both clock network and functional block delays. Typically, varia...
Sari Onaissi, Khaled R. Heloue, Farid N. Najm
PASTE
2010
ACM
15 years 8 months ago
Opportunities for concurrent dynamic analysis with explicit inter-core communication
Multicore is now the dominant processor trend, and the number of cores is rapidly increasing. The paradigm shift to multicore forces the redesign of the software stack, which incl...
Jungwoo Ha, Stephen P. Crago
ATAL
2009
Springer
15 years 6 months ago
Choice, interoperability, and conformance in interaction protocols and service choreographies
Many real-world applications of multiagent systems require independently designed (heterogeneous) and operated (autonomous) agents to interoperate. We consider agents who offer bu...
Matteo Baldoni, Cristina Baroglio, Amit K. Chopra,...