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BMCBI
2008
176views more  BMCBI 2008»
14 years 9 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
JCB
2002
116views more  JCB 2002»
14 years 9 months ago
A Novel Approach to Remote Homology Detection: Jumping Alignments
We describe a new algorithm for protein classi cation and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alig...
Rainer Spang, Marc Rehmsmeier, Jens Stoye
HPDC
2010
IEEE
14 years 10 months ago
Modeling sequence and function similarity between proteins for protein functional annotation
A common task in biological research is to predict function for proteins by comparing sequences between proteins of known and unknown function. This is often done using pair-wise ...
Roger Higdon, Brenton Louie, Eugene Kolker
AINA
2008
IEEE
15 years 4 months ago
Introducing Variable Gap Penalties into Three-Sequence Alignment for Protein Sequences
The common-use gap penalty strategies, constant penalty and affine gap penalty, have been adopted in the traditional three-sequence alignment algorithm which considers the inserti...
Che-Lun Hung, Chun-Yuan Lin, Yeh-Ching Chung, Chua...
RECOMB
2006
Springer
15 years 9 months ago
CONTRAlign: Discriminative Training for Protein Sequence Alignment
In this paper, we present CONTRAlign, an extensible and fully automatic framework for parameter learning and protein pairwise sequence alignment using pair conditional random field...
Chuong B. Do, Samuel S. Gross, Serafim Batzoglou