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» A Flexible Algorithm for Pairwise Protein Structure Alignmen...
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134
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WABI
2001
Springer
142views Bioinformatics» more  WABI 2001»
15 years 8 months ago
Pattern Matching and Pattern Discovery Algorithms for Protein Topologies
We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgrap...
Juris Viksna, David Gilbert
138
Voted
BMCBI
2005
115views more  BMCBI 2005»
15 years 3 months ago
Statistical distributions of optimal global alignment scores of random protein sequences
Background: The inference of homology from statistically significant sequence similarity is a central issue in sequence alignments. So far the statistical distribution function un...
Hongxia Pang, Jiaowei Tang, Su-Shing Chen, Shiheng...
89
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ISMB
1996
15 years 4 months ago
Discovering Empirically Conserved Amino Acid Substitution Groups in Databases of Protein Families
Thispaperintroducesa methodfor identifyingempirically conservedaminoacid substitution groups.In contrast with existing approachesthat viewaminoacid substitution as a pairwisepheno...
Thomas D. Wu, Douglas L. Brutlag
145
Voted
BMCBI
2008
135views more  BMCBI 2008»
15 years 3 months ago
Functional site prediction selects correct protein models
Background: The prediction of protein structure can be facilitated by the use of constraints based on a knowledge of functional sites. Without this information it is still possibl...
Vijayalakshmi Chelliah, William R. Taylor
177
Voted
BMCBI
2002
108views more  BMCBI 2002»
15 years 3 months ago
A memory-efficient dynamic programming algorithm for optimal alignment of a sequence to an RNA secondary structure
Background: Covariance models (CMs) are probabilistic models of RNA secondary structure, analogous to profile hidden Markov models of linear sequence. The dynamic programming algo...
Sean R. Eddy