Abstract. In systems biology, the number of models of cellular processes increases rapidly, but re-using models in different contexts or for different questions remains a challengi...
Motivation: The functioning of biological networks depends in large part on their complex underlying structure. When studying their systemic nature many modeling approaches focus ...
Gene networks describe functional pathways in a given cell or tissue, representing processes such as metabolism, gene expression regulation, and protein or RNA transport. Thus, le...
Biopathway databases have been developed, such as KEGG and EcoCyc, that compile interaction structures of biopathways together with biological annotations. However, these biopathw...
This paper extends our previous work by exploring the use of a hybrid solution method for solving the connection subgraph problem. We employ a two phase solution method, which dras...
Carla P. Gomes, Willem Jan van Hoeve, Ashish Sabha...