385 search results - page 50 / 77 » A Knowledge-Based Method for Protein Structure Refinement an... |
116
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BMCBI
2008
15 years 1 months ago
2008
Background: The principles of protein folding and evolution pose problems of very high inherent complexity. Often these problems are tackled using simplified protein models, e.g. ...
BMCBI
2008
15 years 1 months ago
2008
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
138
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BMCBI
2010
15 years 1 months ago
2010
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
117
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BMCBI
2006
15 years 1 months ago
2006
Background: Measuring each protein's importance in signaling networks helps to identify the crucial proteins in a cellular process, find the fragile portion of the biology sy...
103
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BMCBI
2006
15 years 1 months ago
2006
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...