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NAR
2010
129views more  NAR 2010»
14 years 8 months ago
PROSESS: a protein structure evaluation suite and server
PROSESS (PROtein Structure Evaluation Suite and Server) is a web server designed to evaluate and validate protein structures generated by X-ray crystallography, NMR spectroscopy o...
Mark V. Berjanskii, Yongjie Liang, Jianjun Zhou, P...
BMCBI
2006
85views more  BMCBI 2006»
15 years 1 months ago
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
Rui Jiang, Hua Yang, Fengzhu Sun, Ting Chen
BMCBI
2004
208views more  BMCBI 2004»
15 years 1 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
JIB
2007
75views more  JIB 2007»
15 years 1 months ago
Mapping protein information to disease terminologies
In order to improve the accessibility of genomic and proteomic information to medical researchers, we have developed a procedure to link biological information on proteins involve...
Anaïs Mottaz, Yum Lina Yip, Patrick Ruch, Ann...
BIBM
2008
IEEE
217views Bioinformatics» more  BIBM 2008»
15 years 8 months ago
Combining Hierarchical Inference in Ontologies with Heterogeneous Data Sources Improves Gene Function Prediction
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating thes...
Xiaoyu Jiang, Naoki Nariai, Martin Steffen, Simon ...