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JCB
2007
144views more  JCB 2007»
14 years 11 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
BMCBI
2008
118views more  BMCBI 2008»
14 years 11 months ago
MetWAMer: eukaryotic translation initiation site prediction
Background: Translation initiation site (TIS) identification is an important aspect of the gene annotation process, requisite for the accurate delineation of protein sequences fro...
Michael E. Sparks, Volker Brendel
GCB
1998
Springer
78views Biometrics» more  GCB 1998»
15 years 3 months ago
Computational approaches to identify Leucine Zippers
The leucine zipper is a dimerization domain occurring mostly in regulatory and thus in many oncogenic proteins. The leucine repeat in the sequence has been traditionally used for ...
Erich Bornberg-Bauer
ICML
2007
IEEE
16 years 15 days ago
An integrated approach to feature invention and model construction for drug activity prediction
We present a new machine learning approach for 3D-QSAR, the task of predicting binding affinities of molecules to target proteins based on 3D structure. Our approach predicts bind...
David Page, Jesse Davis, Soumya Ray, Vítor ...
JUCS
2006
141views more  JUCS 2006»
14 years 11 months ago
Constraint Based Methods for Biological Sequence Analysis
: The need for processing biological information is rapidly growing, owing to the masses of new information in digital form being produced at this time. Old methodologies for proce...
Maryam Bavarian, Verónica Dahl