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» A Machine-Learning Strategy for Protein Analysis
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BMCBI
2006
180views more  BMCBI 2006»
14 years 10 months ago
The Gaggle: An open-source software system for integrating bioinformatics software and data sources
Background: Systems biologists work with many kinds of data, from many different sources, using a variety of software tools. Each of these tools typically excels at one type of an...
Paul T. Shannon, David J. Reiss, Richard Bonneau, ...
COLT
2005
Springer
15 years 3 months ago
General Polynomial Time Decomposition Algorithms
We present a general decomposition algorithm that is uniformly applicable to every (suitably normalized) instance of Convex Quadratic Optimization and efficiently approaches an o...
Nikolas List, Hans-Ulrich Simon
GECCO
2010
Springer
191views Optimization» more  GECCO 2010»
15 years 2 months ago
Initialization parameter sweep in ATHENA: optimizing neural networks for detecting gene-gene interactions in the presence of sma
Recent advances in genotyping technology have led to the generation of an enormous quantity of genetic data. Traditional methods of statistical analysis have proved insufficient i...
Emily Rose Holzinger, Carrie C. Buchanan, Scott M....
BMCBI
2006
134views more  BMCBI 2006»
14 years 10 months ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
BMCBI
2008
108views more  BMCBI 2008»
14 years 10 months ago
A nonparametric model for quality control of database search results in shotgun proteomics
Background: Analysis of complex samples with tandem mass spectrometry (MS/MS) has become routine in proteomic research. However, validation of database search results creates a bo...
Jiyang Zhang, Jianqi Li, Xin Liu, Hongwei Xie, Yun...