532 search results - page 55 / 107 » A Methodology for Comparative Functional Genomics |
BMCBI
2008
14 years 9 months ago
2008
Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
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BMCBI
2005
14 years 9 months ago
2005
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
BMCBI
2010
14 years 7 months ago
2010
Background: DNA instability profiles have been used recently for predicting the transcriptional start site and the location of core promoters, and to gain insight into promoter ac...
BMCBI
2010
14 years 9 months ago
2010
Background: The rapid development of structural genomics has resulted in many "unknown function" proteins being deposited in Protein Data Bank (PDB), thus, the functiona...
BMCBI
2006
14 years 9 months ago
2006
Background: Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defini...