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BIOINFORMATICS
2005
140views more  BIOINFORMATICS 2005»
14 years 11 months ago
Profile-based direct kernels for remote homology detection and fold recognition
Motivation: Remote homology detection between protein sequences is a central problem in computational biology. Supervised learning algorithms based on support vector machines are ...
Huzefa Rangwala, George Karypis
CORR
2010
Springer
157views Education» more  CORR 2010»
14 years 12 months ago
Efficient Clustering with Limited Distance Information
Given a point set S and an unknown metric d on S, we study the problem of efficiently partitioning S into k clusters while querying few distances between the points. In our model ...
Konstantin Voevodski, Maria-Florina Balcan, Heiko ...
GECCO
2004
Springer
137views Optimization» more  GECCO 2004»
15 years 5 months ago
Evolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
Luke Sheneman, James A. Foster
NAR
2011
257views Computer Vision» more  NAR 2011»
14 years 2 months ago
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. To...
Damian Szklarczyk, Andrea Franceschini, Michael Ku...
BMCBI
2010
122views more  BMCBI 2010»
14 years 6 months ago
Functional enrichment analyses and construction of functional similarity networks with high confidence function prediction by PF
Background: A new paradigm of biological investigation takes advantage of technologies that produce large high throughput datasets, including genome sequences, interactions of pro...
Troy Hawkins, Meghana Chitale, Daisuke Kihara