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» A New Approach to Pseudoword Generation
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BMCBI
2010
156views more  BMCBI 2010»
15 years 1 months ago
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...
James H. Bullard, Elizabeth Purdom, Kasper D. Hans...
118
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BMCBI
2010
109views more  BMCBI 2010»
15 years 1 months ago
Predicting gene function using hierarchical multi-label decision tree ensembles
Background: S. cerevisiae, A. thaliana and M. musculus are well-studied organisms in biology and the sequencing of their genomes was completed many years ago. It is still a challe...
Leander Schietgat, Celine Vens, Jan Struyf, Hendri...
BMCBI
2010
136views more  BMCBI 2010»
15 years 1 months ago
Bias correction and Bayesian analysis of aggregate counts in SAGE libraries
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
Russell L. Zaretzki, Michael A. Gilchrist, William...
137
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BMCBI
2010
164views more  BMCBI 2010»
15 years 1 months ago
Flexible network reconstruction from relational databases with Cytoscape and CytoSQL
Background: Molecular interaction networks can be efficiently studied using network visualization software such as Cytoscape. The relevant nodes, edges and their attributes can be...
Kris Laukens, Jens Hollunder, Thanh Hai Dang, Geer...
BMCBI
2007
93views more  BMCBI 2007»
15 years 1 months ago
Representing default knowledge in biomedical ontologies: application to the integration of anatomy and phenotype ontologies
Background: Current efforts within the biomedical ontology community focus on achieving interoperability between various biomedical ontologies that cover a range of diverse domain...
Robert Hoehndorf, Frank Loebe, Janet Kelso, Heinri...