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102
Voted
BMCBI
2010
15 years 21 days ago
2010
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
163
Voted
BMCBI
2007
15 years 21 days ago
2007
Background: Detecting groups of functionally related proteins from their amino acid sequence alone has been a long-standing challenge in computational genome research. Several clu...
120
Voted
BMCBI
2007
15 years 21 days ago
2007
Background: Regulation of gene expression is relevant to many areas of biology and medicine, in the study of treatments, diseases, and developmental stages. Microarrays can be use...
96
Voted
BMCBI
2008
2008
Relating gene expression data on two-component systems to functional annotations in Escherichia coli
15 years 21 days ago
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
96
Voted
BMCBI
2007
15 years 21 days ago
2007
Background: By virtue of their shared ancestry, homologous sequences are similar in their structure and function. Consequently, multiple sequence alignments are routinely used to ...