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BIBM
2009
IEEE
206views Bioinformatics» more  BIBM 2009»
15 years 4 months ago
Application of Kernel Functions for Accurate Similarity Search in Large Chemical Databases
Background: Similaritysearch in chemical structure databases is an important problem with many applications in chemical genomics, drug design, and efficient chemical probe screeni...
Xiaohong Wang, Jun Huan, Aaron M. Smalter, Gerald ...
BMCBI
2004
252views more  BMCBI 2004»
14 years 9 months ago
Applying Support Vector Machines for Gene ontology based gene function prediction
Background: The current progress in sequencing projects calls for rapid, reliable and accurate function assignments of gene products. A variety of methods has been designed to ann...
Arunachalam Vinayagam, Rainer König, Jutta Mo...
BMCBI
2010
182views more  BMCBI 2010»
14 years 9 months ago
L2-norm multiple kernel learning and its application to biomedical data fusion
Background: This paper introduces the notion of optimizing different norms in the dual problem of support vector machines with multiple kernels. The selection of norms yields diff...
Shi Yu, Tillmann Falck, Anneleen Daemen, Lé...
BMCBI
2010
143views more  BMCBI 2010»
14 years 9 months ago
Learning gene regulatory networks from only positive and unlabeled data
Background: Recently, supervised learning methods have been exploited to reconstruct gene regulatory networks from gene expression data. The reconstruction of a network is modeled...
Luigi Cerulo, Charles Elkan, Michele Ceccarelli
BMCBI
2007
96views more  BMCBI 2007»
14 years 9 months ago
Features generated for computational splice-site prediction correspond to functional elements
Background: Accurate selection of splice sites during the splicing of precursors to messenger RNA requires both relatively well-characterized signals at the splice sites and auxil...
Rezarta Islamaj Dogan, Lise Getoor, W. John Wilbur...