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» A Parameterized Algorithm for Protein Structure Alignment
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BMCBI
2006
117views more  BMCBI 2006»
14 years 11 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala
101
Voted
RECOMB
2005
Springer
15 years 12 months ago
Pairwise Local Alignment of Protein Interaction Networks Guided by Models of Evolution
Abstract. With ever increasing amount of available data on protein-protein interaction (PPI) networks and research revealing that these networks evolve at a modular level, discover...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
80
Voted
EVOW
2010
Springer
15 years 3 months ago
Improving Multi-Relief for Detecting Specificity Residues from Multiple Sequence Alignments
A challenging problem in bioinformatics is the detection of residues that account for protein function specificity, not only in order to gain deeper insight in the nature of functi...
Elena Marchiori
BMCBI
2010
116views more  BMCBI 2010»
14 years 11 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
80
Voted
CIBCB
2006
IEEE
15 years 5 months ago
Prediction of the Number of Helices for the Twilight Zone Proteins
– Protein structure prediction is one of the core research areas in bioinformatics. This paper addresses the protein secondary structure prediction problem for the twilight zone ...
Kanaka Durga Kedarisetti, Ke Chen, Aashima Kapoor,...