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» A Part-of-Speech-Based Alignment Algorithm
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BMCBI
2010
116views more  BMCBI 2010»
15 years 5 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
152
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FPL
2003
Springer
130views Hardware» more  FPL 2003»
15 years 10 months ago
A Smith-Waterman Systolic Cell
With an aim to understand the information encoded by DNA sequences, databases containing large amount of DNA sequence information are frequently compared and searched for matching ...
Chi Wai Yu, K. H. Kwong, Kin-Hong Lee, Philip Heng...
CGF
2007
156views more  CGF 2007»
15 years 5 months ago
QuadCover - Surface Parameterization using Branched Coverings
We introduce an algorithm for the automatic computation of global parameterizations on arbitrary simplicial 2manifolds, whose parameter lines are guided by a given frame field, f...
Felix Kälberer, Matthias Nieser, Konrad Polth...
BMCBI
2008
145views more  BMCBI 2008»
15 years 5 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
RECOMB
2004
Springer
16 years 5 months ago
Designing multiple simultaneous seeds for DNA similarity search
The challenge of similarity search in massive DNA sequence databases has inspired major changes in BLAST-style alignment tools, which accelerate search by inspecting only pairs of...
Yanni Sun, Jeremy Buhler