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BMCBI
2006
129views more  BMCBI 2006»
14 years 10 months ago
Identifying genes that contribute most to good classification in microarrays
Background: The goal of most microarray studies is either the identification of genes that are most differentially expressed or the creation of a good classification rule. The dis...
Stuart G. Baker, Barnett S. Kramer
BMCBI
2006
115views more  BMCBI 2006»
14 years 10 months ago
Detecting recombination in evolving nucleotide sequences
Background: Genetic recombination can produce heterogeneous phylogenetic histories within a set of homologous genes. These recombination events can be obscured by subsequent resid...
Cheong Xin Chan, Robert G. Beiko, Mark A. Ragan
BMCBI
2006
155views more  BMCBI 2006»
14 years 10 months ago
CAVER: a new tool to explore routes from protein clefts, pockets and cavities
Background: The main aim of this study was to develop and implement an algorithm for the rapid, accurate and automated identification of paths leading from buried protein clefts, ...
Martin Petrek, Michal Otyepka, Pavel Banás,...
BMCBI
2006
203views more  BMCBI 2006»
14 years 10 months ago
Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis dat
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Seon-Young Kim, YongSung Kim
BMCBI
2006
130views more  BMCBI 2006»
14 years 10 months ago
An accurate and interpretable model for siRNA efficacy prediction
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...