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BMCBI
2005
137views more  BMCBI 2005»
14 years 9 months ago
A configuration space of homologous proteins conserving mutual information and allowing a phylogeny inference based on pair-wise
Background: Popular methods to reconstruct molecular phylogenies are based on multiple sequence alignments, in which addition or removal of data may change the resulting tree topo...
Olivier Bastien, Philippe Ortet, Sylvaine Roy, Eri...
BMCBI
2010
155views more  BMCBI 2010»
14 years 7 months ago
BrEPS: a flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation
Background: Models for the simulation of metabolic networks require the accurate prediction of enzyme function. Based on a genomic sequence, enzymatic functions of gene products a...
Constantin Bannert, A. Welfle, C. aus dem Spring, ...
TALG
2010
158views more  TALG 2010»
14 years 4 months ago
Clustering for metric and nonmetric distance measures
We study a generalization of the k-median problem with respect to an arbitrary dissimilarity measure D. Given a finite set P of size n, our goal is to find a set C of size k such t...
Marcel R. Ackermann, Johannes Blömer, Christi...
BMCBI
2010
99views more  BMCBI 2010»
14 years 10 months ago
Prediction of novel precursor miRNAs using a context-sensitive hidden Markov model (CSHMM)
Background: It has been apparent in the last few years that small non coding RNAs (ncRNA) play a very significant role in biological regulation. Among these microRNAs (miRNAs), 22...
Sumeet Agarwal, Candida Vaz, Alok Bhattacharya, As...
BMCBI
2008
128views more  BMCBI 2008»
14 years 10 months ago
SIGffRid: A tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically drive
Background: Many programs have been developed to identify transcription factor binding sites. However, most of them are not able to infer two-word motifs with variable spacer leng...
Fabrice Touzain, Sophie Schbath, Isabelle Debled-R...