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» A Sensitive Sequence Comparison Method
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BMCBI
2007
144views more  BMCBI 2007»
15 years 3 months ago
Application of amino acid occurrence for discriminating different folding types of globular proteins
Background: Predicting the three-dimensional structure of a protein from its amino acid sequence is a long-standing goal in computational/molecular biology. The discrimination of ...
Y.-h. Taguchi, M. Michael Gromiha
BMCBI
2011
14 years 7 months ago
Faster Smith-Waterman database searches with inter-sequence SIMD parallelisation
Background: The Smith-Waterman algorithm for local sequence alignment is more sensitive than heuristic methods for database searching, but also more time-consuming. The fastest ap...
Torbjørn Rognes
108
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BMCBI
2006
92views more  BMCBI 2006»
15 years 3 months ago
Similarity-based gene detection: using COGs to find evolutionarily-conserved ORFs
Background: Experimental verification of gene products has not kept pace with the rapid growth of microbial sequence information. However, existing annotations of gene locations c...
Bradford C. Powell, Clyde A. Hutchison III
ICML
2001
IEEE
16 years 4 months ago
Direct Policy Search using Paired Statistical Tests
Direct policy search is a practical way to solve reinforcement learning problems involving continuous state and action spaces. The goal becomes finding policy parameters that maxi...
Malcolm J. A. Strens, Andrew W. Moore
BMCBI
2008
156views more  BMCBI 2008»
15 years 3 months ago
The unique probe selector: a comprehensive web service for probe design and oligonucleotide arrays
Background: Nucleic acid hybridization, a fundamental technique in molecular biology, can be modified into very effective and sensitive methods for detecting particular targets mi...
Shu-Hwa Chen, Chen-Zen Lo, Ming-Chi Tsai, Chao A. ...