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» A Sequence Alignment Model Based on the Averaged Perceptron
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113
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BMCBI
2004
196views more  BMCBI 2004»
15 years 9 days ago
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Background: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUS...
Robert C. Edgar
105
Voted
BMEI
2008
IEEE
15 years 7 months ago
A New Approach for Tree Alignment Based on Local Re-Optimization
Multiple sequence alignment is the most fundamental task in bioinformatics and computational biology. In this paper, we present a new algorithm to conduct multiple sequences align...
Feng Yue, Jijun Tang
128
Voted
BMCBI
2005
122views more  BMCBI 2005»
15 years 10 days ago
Bayesian coestimation of phylogeny and sequence alignment
Background: Two central problems in computational biology are the determination of the alignment and phylogeny of a set of biological sequences. The traditional approach to this p...
Gerton Lunter, István Miklós, Alexei...
93
Voted
BMCBI
2010
154views more  BMCBI 2010»
15 years 17 days ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...
BMCBI
2008
114views more  BMCBI 2008»
15 years 17 days ago
Dinucleotide controlled null models for comparative RNA gene prediction
Background: Comparative prediction of RNA structures can be used to identify functional noncoding RNAs in genomic screens. It was shown recently by Babak et al. [BMC Bioinformatic...
Tanja Gesell, Stefan Washietl