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    BMCBI
    2006
    145views more  BMCBI 2006»
    GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
    14 years 11 months ago
    GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
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    Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
    Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
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    BMCBI
    2008
    118views more  BMCBI 2008»
    Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
    14 years 11 months ago
    Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
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    Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
    Rekin's Janky, Jacques van Helden
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    BMCBI
    2004
    177views more  BMCBI 2004»
    Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
    14 years 11 months ago
    Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
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    Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
    Andrew F. Neuwald, Jun S. Liu
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