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» A Transcriptional Approach to Gene Clustering
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BMCBI
2007
146views more  BMCBI 2007»
13 years 6 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
PPSN
2004
Springer
13 years 11 months ago
Searching Transcriptional Modules Using Evolutionary Algorithms
The mechanism of gene regulation has been studied intensely for decades. It is important to identify synergistic transcriptional motifs. Its search space is so large that an effici...
Je-Gun Joung, Sok June Oh, Byoung-Tak Zhang
BMCBI
2006
122views more  BMCBI 2006»
13 years 6 months ago
Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle
Background: A transcriptional regulatory module (TRM) is a set of genes that is regulated by a common set of transcription factors (TFs). By organizing the genome into TRMs, a liv...
Wei-Sheng Wu, Wen-Hsiung Li, Bor-Sen Chen
BMCBI
2007
136views more  BMCBI 2007»
13 years 6 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
BIBE
2007
IEEE
195views Bioinformatics» more  BIBE 2007»
14 years 18 days ago
Finding Clusters of Positive and Negative Coregulated Genes in Gene Expression Data
— In this paper, we propose a system for finding partial positive and negative coregulated gene clusters in microarray data. Genes are clustered together if they show the same p...
Kerstin Koch, Stefan Schönauer, Ivy Jansen, J...