We introduce the data model BM, which specifies kernels of motifs by means of Boolean matrices. Different from position frequency matrices these only specify which bases can appea...
Motivation Accurate knowledge of the genome-wide binding of transcription factors in a particular cell type or under a particular condition is necessary for understanding transcri...
Gabriel Cuellar-Partida, Fabian A. Buske, Robert C...
Background: A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-b...
Modern search engines have to be fast to satisfy users, so there are hard back-end latency requirements. The set of features useful for search ranking functions, though, continues...
Feng Pan, Tim Converse, David Ahn, Franco Salvetti...
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...