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BMCBI
2010
214views more  BMCBI 2010»
14 years 9 months ago
AutoSOME: a clustering method for identifying gene expression modules without prior knowledge of cluster number
Background: Clustering the information content of large high-dimensional gene expression datasets has widespread application in "omics" biology. Unfortunately, the under...
Aaron M. Newman, James B. Cooper
BMCBI
2010
86views more  BMCBI 2010»
14 years 9 months ago
Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective
Background: A protein binding hot spot is a small cluster of residues tightly packed at the center of the interface between two interacting proteins. Though a hot spot constitutes...
Qian Liu, Jinyan Li
BMCBI
2010
142views more  BMCBI 2010»
14 years 9 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
BMCBI
2008
102views more  BMCBI 2008»
14 years 9 months ago
PhyloNet: a software package for analyzing and reconstructing reticulate evolutionary relationships
Background: Phylogenies, i.e., the evolutionary histories of groups of taxa, play a major role in representing the interrelationships among biological entities. Many software tool...
Cuong Than, Derek A. Ruths, Luay Nakhleh
CORR
2008
Springer
173views Education» more  CORR 2008»
14 years 9 months ago
Decomposition Principles and Online Learning in Cross-Layer Optimization for Delay-Sensitive Applications
In this paper, we propose a general cross-layer optimization framework in which we explicitly consider both the heterogeneous and dynamically changing characteristics of delay-sens...
Fangwen Fu, Mihaela van der Schaar