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95
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BMCBI
2006
137views more  BMCBI 2006»
14 years 11 months ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
123
Voted
AB
2008
Springer
15 years 5 months ago
An Algorithm for Qualitative Simulation of Gene Regulatory Networks with Steep Sigmoidal Response Functions
A specific class of ODEs has been shown to be adequate to describe the essential features of the complex dynamics of Gene-Regulatory Networks (GRN). But, the effective exploitatio...
Liliana Ironi, Luigi Panzeri, Erik Plahte
96
Voted
BMCBI
2011
14 years 2 months ago
RegNetB: Predicting Relevant Regulator-Gene Relationships in Localized Prostate Tumor Samples
Background: A central question in cancer biology is what changes cause a healthy cell to form a tumor. Gene expression data could provide insight into this question, but it is dif...
Angel Alvarez, Peter J. Woolf
93
Voted
BMCBI
2007
113views more  BMCBI 2007»
14 years 11 months ago
CoryneRegNet 4.0 - A reference database for corynebacterial gene regulatory networks
Background: Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression) and on transcriptional regulatory interactions of micr...
Jan Baumbach
84
Voted
BMCBI
2006
87views more  BMCBI 2006»
14 years 11 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen