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» A factor analysis model for functional genomics
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RECOMB
2005
Springer
15 years 10 months ago
Modeling the Combinatorial Functions of Multiple Transcription Factors
A considerable fraction of yeast gene promoters are bound by multiple transcription factors. To study the combinatorial interactions of multiple transcription factors is thus impor...
Chen-Hsiang Yeang, Tommi Jaakkola
BMCBI
2010
113views more  BMCBI 2010»
14 years 9 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
BMCBI
2008
132views more  BMCBI 2008»
14 years 9 months ago
The SeqWord Genome Browser: an online tool for the identification and visualization of atypical regions of bacterial genomes thr
Background: Data mining in large DNA sequences is a major challenge in microbial genomics and bioinformatics. Oligonucleotide usage (OU) patterns provide a wealth of information f...
Hamilton Ganesan, Anna S. Rakitianskaia, Colin F. ...
ECML
2006
Springer
15 years 1 months ago
Unsupervised Multiple-Instance Learning for Functional Profiling of Genomic Data
Multiple-instance learning (MIL) is a popular concept among the AI community to support supervised learning applications in situations where only incomplete knowledge is available....
Corneliu Henegar, Karine Clément, Jean-Dani...
69
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BMCBI
2010
240views more  BMCBI 2010»
14 years 9 months ago
CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse
Background: Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinforma...
Olivier Friard, Angela Re, Daniela Taverna, Michel...