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» A factor model to analyze heterogeneity in gene expression
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BMCBI
2010
144views more  BMCBI 2010»
14 years 9 months ago
Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model
Background: Large-scale genomic studies often identify large gene lists, for example, the genes sharing the same expression patterns. The interpretation of these gene lists is gen...
Xin He, Moushumi Sen Sarma, Xu Ling, Brant W. Chee...
IPPS
2003
IEEE
15 years 2 months ago
Gene Clustering Using Self-Organizing Maps and Particle Swarm Optimization
Gene clustering, the process of grouping related genes in the same cluster, is at the foundation of different genomic studies that aim at analyzing the function of genes. Microarr...
Xiang Xiao, Ernst R. Dow, Russell C. Eberhart, Zin...
BMCBI
2007
167views more  BMCBI 2007»
14 years 9 months ago
A stochastic differential equation model for transcriptional regulatory networks
Background: This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data se...
Adriana Climescu-Haulica, Michelle D. Quirk
BMCBI
2006
145views more  BMCBI 2006»
14 years 9 months ago
Fast-Find: A novel computational approach to analyzing combinatorial motifs
Background: Many vital biological processes, including transcription and splicing, require a combination of short, degenerate sequence patterns, or motifs, adjacent to defined seq...
Micah Hamady, Erin Peden, Rob Knight, Ravinder Sin...
BMCBI
2010
160views more  BMCBI 2010»
14 years 9 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian