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» A factor model to analyze heterogeneity in gene expression
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BMCBI
2008
128views more  BMCBI 2008»
14 years 9 months ago
Finding sequence motifs with Bayesian models incorporating positional information: an application to transcription factor bindin
Background: Biologically active sequence motifs often have positional preferences with respect to a genomic landmark. For example, many known transcription factor binding sites (T...
Nak-Kyeong Kim, Kannan Tharakaraman, Leonardo Mari...
BMCBI
2008
138views more  BMCBI 2008»
14 years 9 months ago
M-BISON: Microarray-based integration of data sources using networks
Background: The accurate detection of differentially expressed (DE) genes has become a central task in microarray analysis. Unfortunately, the noise level and experimental variabi...
Bernie J. Daigle Jr., Russ B. Altman
BIOCOMP
2006
14 years 11 months ago
Computational Inference of Compound-induced Anti-inflammatory Effects Across Time in an Adjuvant-induced Arthritis Rat Model
A number of diseases, such as arthritis and cardiovascular disorders impacting the lives of many people have strong inflammatory components. To elucidate the antiinflammatory mecha...
Jing Yu, Gabriel Helmlinger, Muriel Saulnier, Anna...
JAMIA
2011
94views more  JAMIA 2011»
14 years 17 days ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...

Publication
197views
13 years 5 months ago
Convex non-negative matrix factorization for massive datasets
Non-negative matrix factorization (NMF) has become a standard tool in data mining, information retrieval, and signal processing. It is used to factorize a non-negative data matrix ...
C. Thurau, K. Kersting, M. Wahabzada, and C. Bauck...