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» A graphical model for protein secondary structure prediction
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JCB
2007
144views more  JCB 2007»
15 years 16 days ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
126
Voted
BMCBI
2011
14 years 4 months ago
GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and ...
Catherine L. Worth, Annika Kreuchwig, Gunnar Klein...
108
Voted
ESA
2005
Springer
136views Algorithms» more  ESA 2005»
15 years 6 months ago
Approximating the 2-Interval Pattern Problem
We address the problem of approximating the 2-Interval Pattern problem over its various models and restrictions. This problem, which is motivated by RNA secondary structure predict...
Maxime Crochemore, Danny Hermelin, Gad M. Landau, ...
104
Voted
BMCBI
2007
135views more  BMCBI 2007»
15 years 22 days ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
82
Voted
BMCBI
2010
93views more  BMCBI 2010»
15 years 22 days ago
Hybridization thermodynamics of NimbleGen Microarrays
Background: While microarrays are the predominant method for gene expression profiling, probe signal variation is still an area of active research. Probe signal is sequence depend...
Ulrike Mückstein, Germán G. Leparc, Al...