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BMCBI
2008
173views more  BMCBI 2008»
14 years 10 months ago
Improved machine learning method for analysis of gas phase chemistry of peptides
Background: Accurate peptide identification is important to high-throughput proteomics analyses that use mass spectrometry. Search programs compare fragmentation spectra (MS/MS) o...
Allison Gehrke, Shaojun Sun, Lukasz A. Kurgan, Nat...
BMCBI
2006
128views more  BMCBI 2006»
14 years 9 months ago
Comparative assessment of performance and genome dependence among phylogenetic profiling methods
Background: The rapidly increasing speed with which genome sequence data can be generated will be accompanied by an exponential increase in the number of sequenced eukaryotes. Wit...
Evan S. Snitkin, Adam M. Gustafson, Joseph C. Mell...
BMCBI
2005
130views more  BMCBI 2005»
14 years 9 months ago
Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome
Background: This paper addresses the problem of recognising DNA cis-regulatory modules which are located far from genes. Experimental procedures for this are slow and costly, and ...
Irina I. Abnizova, Rene te Boekhorst, Klaudia Walt...
BMCBI
2006
152views more  BMCBI 2006»
14 years 9 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
BMCBI
2007
107views more  BMCBI 2007»
14 years 10 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai