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BMCBI
2006
156views more  BMCBI 2006»
14 years 9 months ago
Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models
Background: Horizontal gene transfer (HGT) is considered a strong evolutionary force shaping the content of microbial genomes in a substantial manner. It is the difference in spee...
Stephan Waack, Oliver Keller, Roman Asper, Thomas ...
BMCBI
2010
114views more  BMCBI 2010»
14 years 9 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
BMCBI
2010
183views more  BMCBI 2010»
14 years 9 months ago
Active learning for human protein-protein interaction prediction
Background: Biological processes in cells are carried out by means of protein-protein interactions. Determining whether a pair of proteins interacts by wet-lab experiments is reso...
Thahir P. Mohamed, Jaime G. Carbonell, Madhavi Gan...
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BMCBI
2006
125views more  BMCBI 2006»
14 years 9 months ago
Automated functional classification of experimental and predicted protein structures
Background: Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural si...
Kai Wang, Ram Samudrala
NAR
2011
198views Computer Vision» more  NAR 2011»
14 years 17 days ago
PhylomeDB v3.0: an expanding repository of genome-wide collections of trees, alignments and phylogeny-based orthology and paralo
The growing availability of complete genomic sequences from diverse species has brought about the need to scale up phylogenomic analyses, including the reconstruction of large col...
Jaime Huerta-Cepas, Salvador Capella-Gutiér...