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BMCBI
2008
109views more  BMCBI 2008»
14 years 10 months ago
Merging microsatellite data: enhanced methodology and software to combine genotype data for linkage and association analysis
Background: Correctly merged data sets that have been independently genotyped can increase statistical power in linkage and association studies. However, alleles from microsatelli...
Angela P. Presson, Eric M. Sobel, Paivi Pajukanta,...
BMCBI
2010
121views more  BMCBI 2010»
14 years 10 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
ICDE
2008
IEEE
190views Database» more  ICDE 2008»
15 years 11 months ago
Adaptive Segmentation for Scientific Databases
In this paper we explore database segmentation in the context of a column-store DBMS targeted at a scientific database. We present a novel hardware- and scheme-oblivious segmentati...
Milena Ivanova, Martin L. Kersten, Niels Nes
RECOMB
2004
Springer
15 years 10 months ago
Computational identification of evolutionarily conserved exons
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multispecies version of the ab initio gene prediction problem. These models ...
Adam C. Siepel, David Haussler
BMCBI
2008
131views more  BMCBI 2008»
14 years 10 months ago
CoCoNUT: an efficient system for the comparison and analysis of genomes
Background: Comparative genomics is the analysis and comparison of genomes from different species. This area of research is driven by the large number of sequenced genomes and hea...
Mohamed Ibrahim Abouelhoda, Stefan Kurtz, Enno Ohl...