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» A polyhedral approach to sequence alignment problems
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WABI
2007
Springer
102views Bioinformatics» more  WABI 2007»
15 years 3 months ago
Homology Search with Fragmented Nucleic Acid Sequence Patterns
The comprehensive annotation of non-coding RNAs in newly sequenced genomes is still a largely unsolved problem because many functional RNAs exhibit not only poorly conserved sequen...
Axel Mosig, Julian J.-L. Chen, Peter F. Stadler
AAAI
2004
14 years 11 months ago
Space-Efficient Memory-Based Heuristics
A memory-based heuristic is a heuristic function that is stored in a lookup table. Very accurate heuristics have been created by building very large lookup tables, sometimes calle...
Rong Zhou, Eric A. Hansen
ICASSP
2007
IEEE
15 years 3 months ago
Evolutionary Sequence Modeling for Discovery of Peptide Hormones
There are currently a large number of ‘‘orphan’’ G-protein-coupled receptors (GPCRs) whose endogenous ligands (peptide hormones) are unknown. Identification of these pepti...
M. Kemal Sönmez, Lawrence Toll, Nina Zaveri
BMCBI
2004
208views more  BMCBI 2004»
14 years 9 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
BMCBI
2006
166views more  BMCBI 2006»
14 years 9 months ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...