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» A polyhedral approach to sequence alignment problems
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WABI
2007
Springer
102views Bioinformatics» more  WABI 2007»
15 years 5 months ago
Homology Search with Fragmented Nucleic Acid Sequence Patterns
The comprehensive annotation of non-coding RNAs in newly sequenced genomes is still a largely unsolved problem because many functional RNAs exhibit not only poorly conserved sequen...
Axel Mosig, Julian J.-L. Chen, Peter F. Stadler
AAAI
2004
15 years 1 months ago
Space-Efficient Memory-Based Heuristics
A memory-based heuristic is a heuristic function that is stored in a lookup table. Very accurate heuristics have been created by building very large lookup tables, sometimes calle...
Rong Zhou, Eric A. Hansen
ICASSP
2007
IEEE
15 years 6 months ago
Evolutionary Sequence Modeling for Discovery of Peptide Hormones
There are currently a large number of ‘‘orphan’’ G-protein-coupled receptors (GPCRs) whose endogenous ligands (peptide hormones) are unknown. Identification of these pepti...
M. Kemal Sönmez, Lawrence Toll, Nina Zaveri
BMCBI
2004
208views more  BMCBI 2004»
14 years 11 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
BMCBI
2006
166views more  BMCBI 2006»
14 years 11 months ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...